Lucas R. Chadwick


Dr. Lucas R. Chadwick, Vice President
Wrightwood Technologies Inc.
451 W. Wrightwood Ave.
Suite 306
Chicago, IL: 60614
Phone: 312-238-9512
Fax: 312-376-8905
Email: lchadwick@wrightwoodtech.com

 

 

EDUCATION

KalamazooCollege
Bachelor of Arts in Chemistry (with distinction)
Awarded June, 1995


University of Illinois at Chicago (UIC)
Doctor of Philosophy in Pharmacognosy
Awarded May 2004

 

PROFESSIONAL EXPERIENCE

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL
1996–1999 
Teaching Assistant

World Health Organization’s Monographs on Medicinal Plants
1999–2004 
Research Assistant on development

UIC/NIH Center for Botanical Dietary Supplements Research, Project 1 (Standardization), University of Illinois at Chicago, IL
2001–2004 
Research Assistant

UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, IL
2004–2005 
Research Associate (PostDoc)

Kalsec, Inc., Kalamazoo, MI.
2005-present
Research Scientist

Wrightwood Technologies Inc., Chicago, IL.
2006-present
Vice President

 

RESEARCH EXPERTISE, INTERESTS AND SKILLS

PUBLICATIONS AND PRESENTATIONS

Books/Book Chapters

L. Chadwick, H. Fong. Herb Quality Assurance and Standardization in Herb-Drug Interaction Evaluation.  In Herb-Drug Interactions: Scientific and Regulatory Challenges, F. Lam, S. Huang, S. Hall, eds.  Marcel-Dekker Inc. 2006, in press.

International Refereed Journals and Letters

L. Chadwick, C. Wu, A. Kinghorn: Isolation of alkaloids from goldenseal (Hydrastis canadensis) rhizomes using pH-zone refining countercurrent chromatography. Journal of Liquid Chromatography and Related Technologies 24, 2445-2453 (2001)

B. Hwang, S. Roberts, L. Chadwick, C. Wu, A. Kinghorn: Antimicrobial constituents from goldenseal (the rhizomes of Hydrastis canadensis) against selected oral pathogens. Planta Medica 69, 623-627 (2003)

G. Mahady, S. Pendland, L. Chadwick, A. Stoia: Resveratrol and red wine extracts inhibit the growth of CagA+ strains of Helicobacter pylori in vitro. American Journal of Gastroenterology 98, 1440-1441 (2003)

G. Mahady, S. Pendland, A. Stoia, L. Chadwick: In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. Phytotherapy Research 17, 217-221 (2003)

D. Nikolic, Y. Li, L. Chadwick, S. Grubjesic, P. Schwab, P. Metz, R. van Breemen: Metabolism of 8‑prenylnaringenin, a potent phytoestrogen from hops, by human liver microsomes. Drug Metabolism and Disposition 32, 272-279 (2004)

L. Chadwick, D. Nikolic, J. Burdette, C. Overk, J. Bolton, R. van Breemen; R. Fröhlich, H. Fong, N. Farnsworth, G. Pauli: Estrogens and Congeners from Spent Hops (Humulus lupulus L.). Journal of Natural Products 67, 2024-2032 (2004)

G. Mahady, S. Pendland, A. Stoia, F. Hamill, D. Fabricant, B. Dietz, L. Chadwick. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders.  Phytotherapy Research 19, 988-991 (2005)

B. Dietz, Y. Kang, G. Liu, A. Eggler, P. Yao, L. Chadwick, G. Pauli, N. Farnsworth, A. Mesecar, R. van Breemen, J. Bolton. Xanthohumol isolated from Humulus lupulus L. inhibits menadione-induced DNA damage through induction of quinone reductase.  Chemical Research in Toxicology 18, 1296-1305 (2005)

C. Overk, P. Yao, L. Chadwick, D. Nikolic, Y. Sun, M. Cuendet, Y. Deng, A. Hedayat, G. Pauli, N. Farnsworth, R. van Breemen, J. Bolton.  Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense).  Journal of Agricultural and Food Chemistry 16, 6246-6253 (2005)

D. Nikolic, Y. Li, L. Chadwick, G. Pauli, R. van Breemen.  Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.  Journal of Mass Spectrometry 40, 289-299 (2005). 

 W. Conway W, L. Chadwick, H. Fong, N. Farnsworth, G. Pauli.  Extra-Column dead volume in countercurrent chromatography. Journal of Liquid Chromatography and Related Technologies 28, 1799-1818 (2005)

 L. Chadwick, H. Fong, N. Farnsworth, G. Pauli.  CCC sample cutting for isolation of prenylated phenolics from hops. Journal of Liquid Chromatography and Related Technologies 28, 1959-1969 (2005)

L. Chadwick, G. Pauli, N. Farnsworth: The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine 13, 119-131 (2006).

J. Guo, D. Nikolic, L. Chadwick, G. Pauli, R. van Breemen.  Identification of human hepatic cytochrome p450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.) Drug Metabolism and Disposition 34, 1152-1159 (2006)

D. Nikolic, Y. Li, L. Chadwick, R. van Breemen.        In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharmaceutical Research 23, 864-72 (2006)

 

AWARDS, ACHIEVEMENTS, AND RECOGNITIONS

F.W. and E.P. Heyl Scholar
1991-1995
merit-based, four-year, full tuition scholarship to Kalamazoo College (including studies in Ecuador)

UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, IL
2002-2004 
Pre-doctoral Fellowship

College of Pharmacy, University of Illinois at Chicago, IL

2004
Van Doren Scholar

 

ORGANIZATIONS/LEADERSHIP

American Society of Pharmacognosy
Member since 1996

American Chemical Society
Member since 1998

Scientific Advisory Committee, CCC2006 (4th International Conference on Countercurrent Chromatography)
Member since 2004

Studies of ecology, medicinal plants and Spanish language, Universidad San Francisco de Quito, Quito (Ecuador)
1993-1994

Journal of Natural Products, Pharmaceutical Biology, and the Encyclopedia of Dietary Supplements
Reviewer since 2002

Certified for Laboratory Safety & Chemical Waste Management by the University of Illinois at Chicago Environmental Health & Safety Office
2000-2005